Phenylacetic Acid → HCID 87551058, compound

Participants

Reaction Steps

To a solution of phenylacetic acid (61.5 mg, 0.452 mmol) in 10 mL di CH2Cl2 was added PS-carbodiimide 1.25 mmol/g (480 mg, 0.6 mmol), while gently stirring at r.t. After 20 min., the Compound of Example 3 (64 mg, 0.301 mmol) was added. A very slow stirring was maintained overnight. Filtration, followed by washing the resin with CH2Cl2 and evaporation afforded a crude which was purified by flash chromatography (CHCl3-1.4 N MeOH/NH3 100:0.2) yielding the title product (80 mg).

Provenance & Evidence