HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-iodopyrimidine → 5-Bromo-2-{4-[3-(6-methylpyridin-2-yl)prop-2-yn-1-ylidene]piperidin-1-yl}pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-iodopyrimidine | HCID 7006651 | — |
| Reactant | 2-Methyl-6-[3-(1-pyridin-2-ylpiperidin-4-ylidene)prop-1-yn-1-yl]pyridine | HCID 25181639 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 5-Bromo-2-{4-[3-(6-methylpyridin-2-yl)prop-2-yn-1-ylidene]piperidin-1-yl}pyrimidine | HCID 87551213 | 64.1% |
Reaction Steps
The title compound was prepared following the procedure described for the compound of Example 59, but substituting NMP with N,N-dimethylacetamide and substituting 2-fluoropyridine with 5-bromo-2-iodopyrimidine and reacting the mixture at r.t. Purification was carried out by automated flash liquid chromatography (Horizon™-Biotage) eluting with CHCl3-1.4 N MeOH NH3 100:0.5. White solid. Yield: 64.1%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518916B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-88b19d9381ff4c698f6c277232963d01 |
| Source note | uspto-grants-2013_08 |