Tert-butyl 4-[1-hydroxy-3-(6-methylpyridin-2-yl)prop-2-ynyl]piperidine-1-carboxylate → 3-(6-Methyl-pyridin-2-yl)-1-piperidin-4-yl-prop-2-yn-1-ol

HRID 1895992Notes

Reaction equation

HRID 1895992 reaction equation
CC1C=CC=C(C#CC=C2CCNCC2)N=1.[OH:17][CH:18]([CH:28]1[CH2:33][CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29]1)[C:19]#[C:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH3:27])[N:22]=1>>[CH3:27][C:23]1[N:22]=[C:21]([C:20]#[C:19][CH:18]([CH:28]2[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]2)[OH:17])[CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 68725592Tert-butyl 4-[1-hydroxy-3-(6-methylpyridin-2-yl)prop-2-ynyl]piperidine-1-carboxylateHCID 875504022-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

Product 1

HCID 689774953-(6-Methyl-pyridin-2-yl)-1-piperidin-4-yl-prop-2-yn-1-ol

Procedure

The title compound was prepared following the procedure described for the compound of Example 3, using the Compound of Example 39 instead of the Compound of Example 2. After the usual work-up procedure, the crude was used in the next step without further purification.

Workup

  1. customAfter the usual work-up procedure, the crude was used in the next step without further purification

Sources & evidence

ORD record
ord-4517455cfc04487fa2d27d7eb5470dec
Source dataset
uspto-grants-2013_08
Patent number
US08518916B2

Reaction notes

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