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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1895994Generated: October 31, 2026

2-Chloro-3-nitrothiophene → HCID 25181793, compound

https://huagongshe.com/reaction/1895994

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-3-nitrothiopheneHCID 220186—
Reactant3-(6-Methyl-pyridin-2-yl)-1-piperidin-4-yl-prop-2-yn-1-olHCID 68977495—
Reactant2-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridineHCID 87550402—
ProductHCID 25181793HCID 25181793—

Reaction Steps

The title compound was prepared following the procedure described for the compound of Example 237, using the Compound of Example 3 instead of Compound 237a and 2-chloro-3-nitrothiophene instead of 2-bromo-3-nitropyridine. The crude was purified by automated flash liquid chromatography (Horizon™-Biotage) eluting with Petroleum Ether-EtOAc 1:1 affording the title product as a yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08518916B2
Source datasetuspto-grants-2013_08
ORD IDord-42635e9ee468465d8b382b730ca33f90
Source noteuspto-grants-2013_08