HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-methyl-3-nitropyridine → 2-{4-[1-Fluoro-3-(6-methylpyridin-2-yl)prop-2-ynyl]piperidin-1-yl}-6-methyl-3-nitropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-methyl-3-nitropyridine | HCID 1268230 | — |
| Reactant | 3-(6-Methyl-pyridin-2-yl)-1-piperidin-4-yl-prop-2-yn-1-ol | HCID 68977495 | — |
| Reactant | 2-(3-Fluoro-3-piperidin-4-yl-prop-1-ynyl)-6-methyl-pyridine | HCID 68977733 | — |
| Product | 2-{4-[1-Fluoro-3-(6-methylpyridin-2-yl)prop-2-ynyl]piperidin-1-yl}-6-methyl-3-nitropyridine | HCID 68724880 | — |
Reaction Steps
The title compound was prepared following the procedure described for the compound of Example 237, using Compound 251a instead of Compound 237a and 2-chloro-3-nitro-6-picoline instead of 2-bromo-3-nitropyridine. The crude was purified by automated flash liquid chromatography (Horizon™-Biotage) eluting with Petroleum Ether-EtOAc 9:1, affording the title product as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518916B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-c0661c013c1c4c3da7633941be8daed1 |
| Source note | uspto-grants-2013_08 |