Water → HCID 86627345, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Compound 255a (752 mg, 2.51 mmol) in CHCl3 (15 mL) was added trifluoroacetic acid (0.967 mL, 12.6 mmol) and the reaction mixture was stirred at 25° C. for 24 h, until the complete conversion of the reagent was observed by LC-MS. Water was added followed by aq. NaOH (2 N) to give alkaline pH. Separation of the organic layer and extraction of the aqueous layer with CH2Cl2, washing with brine and drying over Na2SO4 the combined organic layers, afforded the title compound. The crude was purified by flash chromatography (CHCl3-1.6 M methanolic ammonia 100:5) affording the title product (359 mg).

Provenance & Evidence