反应详情

温度

-75 °C

Boron trifluoride diethyl etherate (0.131 mL, 1.03 mmol) followed by lithium phenylacetylide (1M in THF, 1.03 mL, 1.03 mmol) was dropped into a solution of Compound 256a (200 mg, 0.938 mmol) in THF (5 mL) stirred at −75° C. under nitrogen atmosphere. Stirring and cooling were kept on for 2 h and after overnight stirring at r.t., the reaction mixture was quenched with water and EtOAc. The combined extracts were washed, dried over Na2SO4 and evaporated to dryness. The residue was purified by flash chromatography (EtOAc—Petroleum Ether 85:15) affording the title product (272 mg).

1. stirringStirring
2. temperaturecooling
3. stirringstirring at r.t.
4. customthe reaction mixture was quenched with water and EtOAc
5. washThe combined extracts were washed
6. dry with materialdried over Na2SO4
7. customevaporated to dryness
8. customThe residue was purified by flash chromatography (EtOAc—Petroleum Ether 85:15)