HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1896020Generated: October 27, 2026
Carbon tetrabromide → 2-[4-(3-Bromoprop-2-ynylidene)piperidin-1-yl]-3-nitropyridine
https://huagongshe.com/reaction/1896020
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Carbon tetrabromide | HCID 11205 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 3-Nitro-2-(4-prop-2-ynylidenepiperidin-1-yl)pyridine | HCID 86627335 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 2-[4-(3-Bromoprop-2-ynylidene)piperidin-1-yl]-3-nitropyridine | HCID 86762014 | — |
Reaction Steps
A mixture of Compound 1c (200 mg, 0.82 mmol), CBr4 (0.54 mg, 1.65 mmol), potassium hydroxide (0.138 mg, 2.46 mmol), 18-C-6 crown ether (21.8 mg, 0.823 mmol) and 10 mL of benzene was stirred at 65° C. for 11 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08518916B2 |
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| Source dataset | uspto-grants-2013_08 |
|---|
| ORD ID | ord-8ab1c961ce344584997291f1b9911867 |
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| Source note | uspto-grants-2013_08 |
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