HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromothiophene-3-carbonitrile → 2-{4-[3-(6-Methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl}thiophene-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromothiophene-3-carbonitrile | HCID 12079026 | — |
| Reactant | 4-{4-[3-(6-Methylpyridin-2-yl)prop-2-yn-1-ylidene]piperidin-1-yl}isoquinoline | HCID 87551162 | — |
| Product | 2-{4-[3-(6-Methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl}thiophene-3-carbonitrile | HCID 25181787 | 22% |
Reaction Steps
Following the procedure reported for the compound of Example 234 and using 2-bromo-3-cyanothiophene instead of 4-bromoisoquinoline the title compound was prepared. Purification was done by RP LC-MS chromatography, using MS-C18 XTerra column 30×50 mm eluting with ammonium bicarbonate 20 mM pH 8 buffer-acetonitrile gradient affording the compound of the title. Yield: 22%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518916B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-ff96c0d047d34df3874e7ae62188f3f8 |
| Source note | uspto-grants-2013_08 |