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HRID1896027

反应详情

EQUATION

反应方程式

HRID 1896027 的结构方程式

REACTANTS

反应物

3
结构：Fc1ccnc(Cl)c1
HCID2782792

2-Chloro-4-fluoropyridine

C5H3ClFN

结构：COc1c(F)cc(C#CC=C2CCN(c3ncccc3[N+](=O)[O-])CC2)cc1F
HCID86627339

未命名化合物

结构：C#CC=C1CCN(C(=O)OC(C)(C)C)CC1
HCID86661548

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCC(=CC#Cc2cc(F)ccn2)CC1
HCID91261370

未命名化合物

收率 38.5%

PROCEDURE

实验过程

The title compound was prepared following the procedure described for the Compound of Example 199, but using Compound 2b instead of Compound 1c and 2-chloro-4-fluoropyridine instead of 4-bromo-2,6-difluoroanisole. After the usual work-up procedure, purification was carried out by automated flash liquid chromatography (Horizon™-Biotage) eluting with PE-EtOAc gradient from 95:5 to 60:40. Yield: 38.5%.

WORKUP

后处理

  1. customAfter the usual work-up procedure, purification
  2. washeluting with PE-EtOAc gradient from 95:5 to 60:40