HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-methylpyridine-3-carbonitrile → HCID 87550782, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-methylpyridine-3-carbonitrile | HCID 520400 | — |
| Reactant | 3-Bromo-5-(trifluoromethyl)pyridine | HCID 11127991 | — |
| Reactant | HCID 25181651 | HCID 25181651 | — |
| Reactant | 2-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine | HCID 87550402 | — |
| Product | HCID 87550782 | HCID 87550782 | 35% |
Reaction Steps
The title compound was synthesized following the procedure described for the Compound of Example 262 replacing 3-bromo-5-(trifluoromethyl)pyridine with 2-chloro-6-methylnicotinonitrile and the compound of Example 3 with Compound 253d. Purification by automated flash chromatography (Horizon™-Biotage) PE-EtOAc 9:1 afforded a colorless oil. Yield: 35%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518916B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-f8e1504325b24e858722a281b7add993 |
| Source note | uspto-grants-2013_08 |