HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine → 2-Bromo-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine | HCID 87550402 | — |
| Reactant | Tert-butyl 4-[3-(6-bromopyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxylate | HCID 87641844 | — |
| Product | 2-Bromo-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine | HCID 87642212 | — |
Reaction Steps
The title product was prepared following the method described for the Compound of Example 3 but using as starting material Compound 305a instead of the Compound of Example 2 and stirring at ambient temperature for 3 days. The reaction mixture was evaporated to dryness in vacuo, taking up the residue several times with chloroform to remove excess trifluoroacetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518916B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-213125f6597a4d6fa6d15b244e585472 |
| Source note | uspto-grants-2013_08 |