反应详情

The title compound was prepared as described for the compound of Example 237 but starting from Compound 310c or 311c instead of compound 237a and using 2-chloro-6-methyl-3-nitropyridine instead of 2-bromo-3-nitropyridine. After the work-up, the residue was purified by automated flash liquid chromatography (SP1™-Biotage) eluting with PE-EtOAc gradient from PE-EtOAc 7:3 to 6:4 affording the title products. Example 310:18%. Example 310: 11%

1. customAfter the work-up, the residue was purified by automated flash liquid chromatography (SP1™-Biotage)
2. washeluting with PE-EtOAc gradient from PE-EtOAc 7:3 to 6:4 affording the title products