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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1896043Generated: November 1, 2026

2-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine → 2-(Piperidin-4-yl)but-3-yn-2-ol

https://huagongshe.com/reaction/1896043

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridineHCID 87550402—
ReactantTert-butyl 4-(1-hydroxy-1-methylprop-2-ynyl)piperidine-1-carboxylateHCID 87550972—
Product2-(Piperidin-4-yl)but-3-yn-2-olHCID 86627358—

Reaction Steps

The title compounds were obtained following the procedure described for the compound of Example 3 and replacing the Compound of Example 2 with Compound 312a refluxing for 6 h. The crude was used without further purification in the next step.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08518916B2
Source datasetuspto-grants-2013_08
ORD IDord-4027678fd64049a5810448a3d002f954
Source noteuspto-grants-2013_08