HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloropyrazine-2-carbonitrile → HCID 25181777, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloropyrazine-2-carbonitrile | HCID 292465 | — |
| Reactant | 3-(6-Methyl-pyridin-2-yl)-1-piperidin-4-yl-prop-2-yn-1-ol | HCID 68977495 | — |
| Reactant | 2-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine | HCID 87550402 | — |
| Product | HCID 25181777 | HCID 25181777 | 81% |
Reaction Steps
The title compound was prepared as reported for the compound of Example 237 but starting from the compound of Example 3 instead of Compound 237a and using 2-chloro-3-cyanopyrazine instead of 2-bromo-3-nitropyridine After the work-up, the residue was purified by automated flash liquid chromatography (SP1™-Biotage) eluting with PE-EtOAc gradient from 7:3 affording the title product. Yellowish solid. Yield: 81%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518916B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-8a36c998fa3e43ac8437abed3617903e |
| Source note | uspto-grants-2013_08 |