反应详情

After dissolving 2-[4-[2-(5,6-difluorobenzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(2,2,2-trifluoroethoxy)-6-methyl-3-pyridyl]acetamide (1.00 g, 1.56 mmol) in ethanol (20 mL), pyridine hydrochloride (360 mg, 3.12 mmol) was added. The reaction mixture was concentrated, and the residue was recrystallized from ethanol to obtain the title compound (787 mg, 78%; including 40% equivalent of ethanol as determined by 1H-NMR) as a colorless crystalline powder.

1. additionwas added
2. concentrationThe reaction mixture was concentrated
3. customthe residue was recrystallized from ethanol