Pyridinium chloride → HCID 10483834, compound

HRID 1896063Notes

Reaction equation

HRID 1896063 reaction equation
[F:1][C:2]([F:37])([F:36])[C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([S:11][CH2:12][CH2:13][N:14]3[CH2:19][CH2:18][N:17]([CH2:20][C:21]([NH:23][C:24]4[C:25]([S:33][CH3:34])=[N:26][C:27]([CH3:32])=[CH:28][C:29]=4[S:30][CH3:31])=[O:22])[CH2:16][CH2:15]3)=[N:8][C:7]=2[CH:35]=1.[ClH:38].N1C=CC=CC=1>C(O)C>[ClH:38].[F:36][C:2]([F:1])([F:37])[C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([S:11][CH2:12][CH2:13][N:14]3[CH2:19][CH2:18][N:17]([CH2:20][C:21]([NH:23][C:24]4[C:25]([S:33][CH3:34])=[N:26][C:27]([CH3:32])=[CH:28][C:29]=4[S:30][CH3:31])=[O:22])[CH2:16][CH2:15]3)=[N:8][C:7]=2[CH:35]=1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 10483835HCID 10483835, compound

Product 1

HCID 10483834HCID 10483834, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-[4-[2-(5-Trifluoromethylbenzoxazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide (200 mg, 0.35 mmol) was dissolved in ethanol (4 mL), followed by the addition of pyridine hydrochloride (82 mg, 0.70 mmol). The reaction mixture was concentrated, and to the residue, ethanol (0.5 mL) and water (5 mL) were added. A precipitate was collected by filtration to obtain the title compound (180 mg, 85%) as a colorless crystalline powder.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additionto the residue, ethanol (0.5 mL) and water (5 mL) were added
  3. filtrationA precipitate was collected by filtration

Sources & evidence

ORD record
ord-3fad575467184c8d92873898daf8e0c7
Source dataset
uspto-grants-2013_08
Patent number
US08518936B2

Reaction notes

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