関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Azide | HCID 33557 | — |
| 反応物 | 9-(3-chloropropyl)-9H-purin-6-amine | HCID 286591 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 9-(3-Azidopropyl)adenine | HCID 12097845 | — |
反応手順
A mixture of 9-(3-chloropropyl)adenine and sodium azide in DMF was stirred at 80° C. for 24 hours, cooled to room temperature and filtered. The solid was washed with CH2Cl2. The solvent was removed from the combined filtrates and the residue was taken up in water with sonication. The aqueous layer was extracted with CH2Cl2. After removing the solvent, the crude product was recrystallized from ethanol to give 9-(3-azidopropyl)adenine as a white crystalline solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08518885B2 |
|---|
| 出典データセット | uspto-grants-2013_08 |
|---|
| ORD ID | ord-dc8e8747d9b6443687f6f629e49ca7d3 |
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| 出典メモ | uspto-grants-2013_08 |
|---|
