HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-3-chloropropane → 1-(3-chloropropyl)-N4-acetylcytosine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-3-chloropropane | HCID 8006 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 178474340 | HCID 178474340 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(3-chloropropyl)-N4-acetylcytosine | HCID 58166061 | — |
Reaction Steps
A mixture of N-acetylcytosine, 1-bromo-3-chloropropane, and potassium carbonate in DMF was stirred at room temperature under argon for 4 days, filtered and evaporated to dryness. The crude product was purified by column chromatography and gave 1-(3-chloropropyl)-N4-acetylcytosine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518885B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-8092625e25f04ed7bbd0dd95aefc6395 |
| Source note | uspto-grants-2013_08 |