Ammonia → 1-(3-Azidopropyl)cytosine

HRID 1896070Notes

Reaction equation

HRID 1896070 reaction equation
[N:1]([CH2:4][CH2:5][CH2:6][N:7]1[CH:17]=[CH:16][C:11]([NH:12]C(=O)C)=[N:10][C:8]1=[O:9])=[N+:2]=[N-:3].N>CO>[N:1]([CH2:4][CH2:5][CH2:6][N:7]1[CH:17]=[CH:16][C:11]([NH2:12])=[N:10][C:8]1=[O:9])=[N+:2]=[N-:3]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 122127661-(3-azidopropyl)-N4-acetylcytosine

Product 1

HCID 122127671-(3-Azidopropyl)cytosine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1-(3-azidopropyl)-N4-acetylcytosine was reacted with 7N ammonia solution in methanol at room temperature for 2 days to give 1-(3-azidopropyl)cytosine as a white solid.

Sources & evidence

ORD record
ord-ac15684b965b45fa84ae5a916721b78c
Source dataset
uspto-grants-2013_08
Patent number
US08518885B2

Reaction notes

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