HuagongsheHuagongshe Chemistry Print Report · For research reference only
Adenine → 9-(3-chloropropyl)-9H-purin-6-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Adenine | HCID 190 | — |
| Reactant | 1-Bromo-3-chloropropane | HCID 8006 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 9-(3-chloropropyl)-9H-purin-6-amine | HCID 286591 | 59% |
Reaction Steps
A mixture of adenine (4.05 g, 30 mM), 1-bromo-3-chloropropane (21.3 g, 13.4 mM), and potassium carbonate (10.4 g, 75 mM) in DMF (200 mL) was stirred at room temperature under argon for 4 days, filtrated, and evaporated to dryness. The crude product was washed with water and dried. Recrystallization from ethanol gave 9-(3-chloropropyl)adenine in 59% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518885B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-e475fa1b02de4f09940ae50d54b7dd4a |
| Source note | uspto-grants-2013_08 |