Sodium Hydroxide → HCID 67377020, compound

Participants

Reaction Conditions

Reaction Steps

As shown in step 1-iv of Scheme 1, Compound 1004 (5.0 g, 13.9 mmol) was taken up in 15 mL of methanol and 30 mL of 6M HCl. After refluxing for 10 hrs, the mixture was cooled to 0° C. and the pH adjusted to 8 with 6M sodium hydroxide. The resulting white precipitate was collected by vacuum filtration, washed well with water, and dried at 55° C. under vacuum for 16 hours to afford 3-(1-(2,3-difluoro-4-methoxyphenyl)-1H-tetrazol-5-yl)pyridin-2-amine (4.2 g): ESMS (M+1)=305.

Provenance & Evidence