HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1,2,3,4,4a,5,6,7-Octahydropyrazino[1,2-a][1,5]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 1,2,4a,5,6,7-hexahydrobenzo[b]pyrazino[1,2-d][1,4]diazepine-3(4h)-carboxylate | HCID 58284934 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1,2,3,4,4a,5,6,7-Octahydropyrazino[1,2-a][1,5]benzodiazepine | HCID 49764421 | — |
Reaction Steps
To a solution of Example 17A (50 mg, 0.165 mmol) in dichloromethane (5 mL) was added HCl (4 M in dioxane, 824 μL, 3.30 mmol). After reaction completion as indicated by LC/MS analysis, the solution was concentrated and purified by preparative HPLC to afford the title compound. 1H NMR (500 MHz, DMSO-d6/D2O) δ ppm 7.48 (t, J=7.48 Hz, 1 H), 7.36 (d, J=7.02 Hz, 1 H), 7.19-7.29 (m, 2 H), 3.47-3.57 (m, 1 H), 3.35-3.44 (m, 2 H), 3.10-3.35 (m, 6 H), 1.76 (s, 2 H); MS (ESI) m/z 204.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518933B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-349a84600ada49e6ba4980ef3ea72fce |
| Source note | uspto-grants-2013_08 |