Hydrochloric Acid → 7-Methyl-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,5]benzodiazepin-6(7h)-one

Participants

Reaction Steps

To a solution of Example 1C (50 mg, 0.16 mmol) in N,N-dimethylformamide (1 mL) was added sodium hydride (65%, 6.98 mg, 0.19 mmol). The solution was allowed to stir at room temperature for 1 hour before addition of methyl iodide (11.77 μL, 0.19 mmol). The reaction mixture was stirred overnight. The solution was concentrated, and dichloromethane (1 mL) was added followed by HCl (4 M in dioxane, 394 μL, 1.6 mmol). After reaction completion as indicated by LC/MS analysis, the solution was concentrated and purified by preparative HPLC to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 7.35 (d, J=7.80 Hz, 1 H), 7.13-7.30 (m, 3 H), 3.32-3.47 (m, 3 H), 3.17-3.32 (m, 5 H), 2.89-3.15 (m, 2 H), 2.62 (dd, J=13.22, 7.12 Hz, 1 H), 2.12 (d, J=13.56 Hz, 1 H); MS (ESI) m/z 231.9 (M+H)+.

Provenance & Evidence