HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1896136Generated: October 30, 2026
Sodium Iodide → 4-Benzyloxy-2-fluoro-1-nitrobenzene
https://huagongshe.com/reaction/1896136
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Fluoro-4-nitrophenol | HCID 520948 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-Benzyloxy-2-fluoro-1-nitrobenzene | HCID 22180704 | — |
Reaction Steps
(Bromomethyl)benzene (10.9 g, 63.7 mmol) and 3-fluoro-4-nitrophenol (10 g, 63.7 mmol) were added to 150 mL acetone followed by potassium carbonate (8.8 g, 63.7 mmol) and sodium iodide (9.54 g, 63.7 mmol). The reaction mixture was heated at 55° C. overnight. The resulting mixture was filtered and concentrated. The crude material was recrystallized in ethyl acetate/hexane to give the title compound. MS (DCI+) m/z 264.9 (M+NH4)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08518933B2 |
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| Source dataset | uspto-grants-2013_08 |
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| ORD ID | ord-d8c5fd7ba69e44e3a03dd87b562967fa |
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| Source note | uspto-grants-2013_08 |
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