HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophene-3-boronic acid → 2-Phenyl-6-(thiophen-3-yl)pyrimidine-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophene-3-boronic acid | HCID 581760 | — |
| Reactant | 6-Chloro-2-phenylpyrimidine-4-carboxylic acid | HCID 57431698 | — |
| Product | 2-Phenyl-6-(thiophen-3-yl)pyrimidine-4-carboxylic acid | HCID 68444293 | — |
Reaction Steps
This compound was prepared using a method analogous to that of Example 32, step 32.1, 6-chloro-2-phenyl-pyrimidine-4-carboxylic acid replacing intermediate 14.1 and thiophene-3-boronic acid replacing phenylboronic acid. The crude was however crystallized (EtOH/H20 2/1). LC-MS (A): tR=1.03 min; [M+H]+: 283.03.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518912B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-b2881ada9da5452398a133824c769373 |
| Source note | uspto-grants-2013_08 |