HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (1-Benzhydrylazetidin-3-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-(Diphenylmethyl)azetidine-3-carboxylic acid | HCID 2735440 | — |
| Reactant | Potassium sodium tartarate | HCID 9855836 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (1-Benzhydrylazetidin-3-yl)methanol | HCID 2758715 | 97.2% |
Reaction Steps
1-Benzhydrylazetane-3-carboxylic acid (101 mg) was dissolved in THF (2 mL) and lithium aluminium hydride (27 mg) was added. The mixture was stirred overnight at RT. Water, sodium potassium tartrate solution and EA were added. The phases were separated, the org. phase was dried (Na2SO4) and evaporated off to afford 93 mg of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518912B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-4182aa1e95a44b2688b037e8742bab44 |
| Source note | uspto-grants-2013_08 |