HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Benzoic acid, 2-hydroxy-3-methyl-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 3-Methylsalicylic Acid | HCID 6738 | — |
| Product | Benzoic acid, 2-hydroxy-3-methyl-, methyl ester | HCID 31835 | — |
Reaction Steps
To a solution of 2-hydroxy-3-methyl-benzoic acid (10 g) in anh. MeOH (80 mL) was added dropwise H2SO4 (10.8 mL). The mixture was refluxed for 24 h and partitioned between DCM and water. The org. phase was separated, dried (Na2SO4) and evaporated off. The crude was purified by solid phase extraction to give the title product as a yellowish liquid (9.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518912B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-78f8518a554f44ce884274b3fcbac5f5 |
| Source note | uspto-grants-2013_08 |