HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 6-Chloropyrazine-2-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 6-Chloropyrazine-2-carboxylic acid | HCID 14500875 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 6-Chloropyrazine-2-carbonyl chloride | HCID 15149671 | — |
Reaction Steps
A mixture of 2-chloro-6-carboxy-pyrazine (1000 mg, 6.3 mmol) in ACN (20 mL) was treated with thionyl chloride (800 uL). The resulting mixture, which became homogeneous upon heating, was refluxed for 2 h. The solvent was removed under reduced pressure which gave an oil. The crude product was used in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518952B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-7d24d020f37a424d9684cf4640cd7d0e |
| Source note | uspto-grants-2013_08 |