HCID 12727115, compound → HCID 12727116, compound

HRID 1896260Notes

Reaction equation

HRID 1896260 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3](/[C:7](/[CH3:14])=[CH:8]/[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:2]=1>[Pd].CCO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]([CH3:14])[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:2]=1

Participants

4

Reactant 1

HCID 12727115HCID 12727115, compound

Product 1

HCID 12727116HCID 12727116, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Palladium on carbon (600 mg, 10 wt. %) was added to a solution of (E)-ethyl 3-(pyridin-3-yl)but-2-enoate (0.60 g, 3.14 mmol) in EtOH (10 ml) and hydrogenated under balloon pressure for 3 h. The reaction mixture was filtered through a pad of celite and washed with EtOH. The filtrate was concentrated and dried under reduced pressure to afford 0.60 g (100%) of ethyl 3-(pyridin-3-yl)butanoate as colorless liquid.

Workup

  1. filtrationThe reaction mixture was filtered through a pad of celite
  2. washwashed with EtOH
  3. concentrationThe filtrate was concentrated
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-d4ff2fb1409c4cf18c6327f80b82b5f9
Source dataset
uspto-grants-2013_08
Patent number
US08518948B2

Reaction notes

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