Ammonia → HCID 67382621, compound

HRID 1896267Notes

Reaction equation

HRID 1896267 reaction equation
[C:1]([NH:4][C@H:5]1[CH2:10][CH2:9][CH2:8][C@H:7]([C:11]([O:13]C)=O)[CH2:6]1)(=[O:3])[CH3:2].[NH3:15]>>[C:1]([NH:4][C@H:5]1[CH2:10][CH2:9][CH2:8][C@H:7]([C:11]([NH2:15])=[O:13])[CH2:6]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 131730828HCID 131730828, compound

Product 1

HCID 67382621HCID 67382621, compoundYield 57.1%

Conditions

Temperature
70 °C

Procedure

Methanolic ammonia (20 ml) was added to trans-methyl 3-acetamidocyclohexanecarboxylate (350 mg, 1.75 mmol), taken in a steel bomb and heated at 70° C. for 18 h. The reaction mixture was concentrated, washed with n-pentane and dried under reduced pressure to afford 200 mg (57.1%) of trans-3-acetamidocyclohexanecarboxamide as white color solid.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. washwashed with n-pentane
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-de0b2a043f4f483391a854fa13857dc3
Source dataset
uspto-grants-2013_08
Patent number
US08518948B2

Reaction notes

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