HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → tert-Butyl (1S,3R)-3-(4-(4-fluoro-2-methoxyphenyl)pyridin-2-ylcarbamoyl)cyclopentylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | 2-Chloro-4-(4-fluoro-2-methoxyphenyl)pyridine | HCID 58432609 | — |
| Reactant | cis-3-(Boc-amino)cyclopentanecarboxamide | HCID 59028693 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | tert-Butyl (1S,3R)-3-(4-(4-fluoro-2-methoxyphenyl)pyridin-2-ylcarbamoyl)cyclopentylcarbamate | HCID 86657559 | — |
Reaction Steps
tert-Butyl (1S,3R)-3-(4-(4-fluoro-2-methoxyphenyl)pyridin-2-ylcarbamoyl)cyclopentylcarbamate was prepared according to Method B using tert-butyl (1S,3R)-3-carbamoylcyclopentylcarbamate (750 mg, 3.28 mmol), 2-chloro-4-(4-fluoro-2-methoxyphenyl)pyridine (930 mg, 3.94 mmol), Cs2CO3 (1.63 g, 4.92 mmol), xantphos (173 mg, 0.29 mmol), Tetrakis(triphenylphosphine)palladium (0) (150 mg, 0.13 mmol) and 1,4-dioxane (10 ml) brought to reaction at 120° C. for 4 h in a sealed tube.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518948B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-510ec2b2f7154eff9660dce73943f3b0 |
| Source note | uspto-grants-2013_08 |