反应详情

温度

100 °C

To a solution of 3-phenyl-1H-pyrazol-5-amine x120 (31.4 mmol, 1 eq, 5 g) in AcOH (30 ml) is added 1,1,3,3-tetraethoxy-2-methylpropane x121 (31.4 mmol, 1 eq, 7.36 g). The mixture is heated at 100° C. during 4 hours. After evaporation of the solvent under reduced pressure, the crude product is poured in saturated NaHCO3 aqueous solution and then extracted with AcOEt. The cumulated organic layers are dried over MgSO4, filtered and evaporated under reduce pressure. The crude mixture is recristallized in AcOEt to afford 6-methyl-2-phenylpyrazolo[1,5-a]pyrimidine x122 as a solid (3 g).

1. customAfter evaporation of the solvent under reduced pressure
2. additionthe crude product is poured in saturated NaHCO3 aqueous solution
3. extractionextracted with AcOEt
4. dry with materialThe cumulated organic layers are dried over MgSO4
5. filtrationfiltered
6. customevaporated