Cesium carbonate → HCID 23582500, compound

Participants

Reaction Steps

A mixture containing 1-amino-8-chloro[1]benzothieno[3,2-c]pyridine-4-carboxamide (Example 1), phenylboronic acid (1.9 equiv), 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazolium chloride (0.2 equiv), cesium carbonate (2.4 equiv), tris(dibenzylideneacetone)dipalladium (0.1 equiv) in dioxane (0.3 M) was placed in a microwave reactor at 120° C. for 23 min. The resulting mixture was extracted with EtOAc-DMSO and H2O. The organic phase was separated and purified by flash chromatography (EtOAc to 10% MeOH in EtOAc) to provide the title compound.

Provenance & Evidence