Butylamine → HCID 56595318, compound

Participants

Reaction Conditions

Reaction Steps

4-Bromo-1-chloro-8-fluoro-5H-pyrido[4,3-b]indole (150 mg, 0.501 mmol) was suspended in n-butylamine (36.1 mg, 0.501 mmol) and heated to 100° C. for 48 hr. After cooling to ambient temperature, the crude reaction mixture was loaded directly onto silica gel for purification (EtOAc/hexanes). The intermediate was processed according to the general procedures outlined in Example 1 Steps E and F to provide the title compound.

Provenance & Evidence