Diglyme → HCID 86639255, compound

Participants

Reaction Conditions

Reaction Steps

4-Bromo-1-chloro-8-fluoro-5H-pyrido[4,3-b]indole (150 mg, 0.501 mmol) and 3H-spiro[2-benzofuran-1,4′-piperidinium]chloride (565 mg, 2.504 mmol) were placed in a vial and suspended in diglyme (3 mL) and Hunig's Base (0.875 mL, 5.01 mmol). The reaction mixture was heated to 150° C. for 4 days. The solution was cooled to ambient temperature, diluted with EtOAc and washed with water. The organic layer was separated, dried over magnesium sulfate, filtered and concentrated. The crude residue was purified on silica gel (EtOAc/hexanes gradient elution).

Provenance & Evidence