Methane → HCID 59198421, compound

Participants

Reaction Steps

A suspension of 4-bromo[1]benzothieno[3,2-c]pyridin-1(2H)-one and CuCN (1.5 equiv) in NMP (0.41 M) was heated to reflux for 1.5 h. The mixture was cooled to room temperature and added to a stirring 2 N HCl solution. The mixture was stirred at room temperature for 1 h, filtered, washed with H2O and dried to give a dark grey solid. The crude product was heated to reflux with activated charcoal in methyl ethyl ketone (MEK) for 0.5 h and filtered through a short pad of silica gel, eluted with more MEK to give after concentration the title compound as a light brown solid.

Provenance & Evidence