Dimethylformamide → HCID 68712754, compound

Participants

Reaction Steps

To a microwave reaction vessel was added 7-bromo-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-4-carbonitrile (Example 12, Step 9), Zn(CN)2 (1.3 equiv), Pd(Ph3P)4 (0.1 equiv), and DMF (0.06 M). After sealing, the tube was degassed via a needle through the septum, and the reaction was set up on the Smith Creator microwave machine for 5 min at 150° C. The mixture was then added to H2O and the resulting solid was collected by filtration and dried under vacuum. The crude was then stirred with 1:10 EtOAc:hexanes containing a trace of acetone, to give after filtration, a pale brown solid which was used as such for the next step.

Provenance & Evidence