Dimethylformamide → HCID 59198475, compound

Participants

Reaction Steps

A suspension of Pd(OAc)2 (0.26 equiv), Pd(Ph3P)4 (0.30 equiv), NaOAc (1.7 equiv) and 7-bromo-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-4-carbonitrile (Example 12, Step 9) in a 1:1 (v/v) mixture of DMF and MeOH (1 M) was stirred at 110° C. under 160 psig of carbon monoxide in a sealed bomb for 18 h. The reaction media was poured in EtOAc and diluted with H2O. The phases were separated and the organic layer washed with brine, dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by flash chromatography using EtOAc and hexanes gradient to yield the title compound.

Provenance & Evidence