Methanol → HCID 23582059, compound

Participants

Reaction Steps

A suspension of methyl methyl 1-amino-4-(aminocarbonyl)[1]benzothieno[3,2-c]pyridine-7-carboxylate (Example 22, Step 2) dissolved in THF and MeOH was treated with a solution of LiOH in H2O (2.5 equiv). The reaction media became cloudy so H2O, MeOH and THF were added until a clear solution ensued. After 18 h, analysis showed consumption of all the starting material. A large proportion of the volatiles were removed under reduced pressure. The remaining solution was treated with 1 N HCl. The precipitate was filtered off to obtain the title compound as a solid.

Provenance & Evidence