HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178510360, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Reactant | HCID 178517587 | HCID 178517587 | — |
| Solvent | N,N-dimethylformamide 1-methyl-2-pyrrolidone | HCID 22708839 | — |
| Product | HCID 178510360 | HCID 178510360 | — |
Reaction Conditions
| Temperature | 150 °C |
|---|
Reaction Steps
A solution of 4-bromo-7-(trifluoromethyl)[1]benzothieno[3,2-c]pyridin-1-ol in a 4:1 mixture of DMF/NMP (0.9 M) in the presence of CuCN (2.5 equiv) was heated in a microwave reactor at 150° C. for 25 min. The reaction was poured into 0.1 N HCl and the title product filtered as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518964B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-123c10c707a04ef59dc36adc1cefa135 |
| Source note | uspto-grants-2013_08 |