HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 68711881, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | HCID 178510358 | HCID 178510358 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 68711881 | HCID 68711881 | — |
Reaction Steps
To a suspension of 1-hydroxy-7-(trifluoromethyl)-5H-pyrido[4,3-b]indole-4-carbonitrile (Example 5, Step 3) and K2CO3 (2.5 equiv) in DMF (0.09 M) at room temperature was added MeI (1.5 equiv). After stirring at room temperature for 30 min, saturated NH4Cl solution was added along with H2O, and EtOAc (same amount as DMF). The resulting suspension was stirred vigorously for 10 min, and the product was then collected by filtration to give the title compound as a beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518964B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-75fc1aba628441e2a8b0aabdce20157d |
| Source note | uspto-grants-2013_08 |