N-bromobutanimide → HCID 86654218, compound

Participants

Reaction Steps

3-Chloro-5-amino-2-(2,2,2-trifluoroethoxy)-pyridine (3.05 g) obtained in Step B was brominated with N-bromosuccinimide (2.4 g) in acetonitrile (68 ml) as described in Example 14, Step C to give 2-bromo-5-chloro-6-trifluoroethoxy-pyridin-3-yl-amine (4.12 g) as a red oil. MS (ES+) 305/307/309 (MH+); 346/348/350 (MH++CH3CN); 1H NMR (400 MHz, CDCl3) 3.80 (br s, 2H), 4.65 (q, 2H), 7.10 (s, 1H).

Provenance & Evidence