Methylglyoxal → HCID 178468239, compound

HRID 1896640Notes

Reaction equation

HRID 1896640 reaction equation
[NH2:1][CH:2]1[CH2:5][N:4]([C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])[CH2:3]1.[O:13]=[C:14]([CH3:17])[CH:15]=O>>[O:13]=[C:14]([CH3:17])/[CH:15]=[N:1]/[CH:2]1[CH2:3][N:4]([C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])[CH2:5]1

Participants

3

Reactant 2

HCID 880MethylglyoxalHCID 1516507Tert-butyl 3-aminoazetidine-1-carboxylate

Product 1

HCID 178468239HCID 178468239, compound

Procedure

A mixture of tert-butyl 3-aminoazetidine-1-carboxylate (16.8 g, 97.5 mmol) and 2-oxopropanal (10 g, 140 mmol) was stirred for 5 minutes at room temperature. The resulting material was purified via silica gel chromatography (Eluant: 1:1 petroleum ether: ethyl acetate) to give the product as an oil, which was used directly in the next step. Yield: 12.5 g, 55.2 mmol, 57%.

Workup

  1. customThe resulting material was purified via silica gel chromatography (Eluant: 1:1 petroleum ether: ethyl acetate)

Sources & evidence

ORD record
ord-578b95f6088e455e94c7b6a335323b5a
Source dataset
uspto-grants-2013_08
Patent number
US08518944B2

Reaction notes

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