反应详情

A mixture of tert-butyl 3-aminoazetidine-1-carboxylate (16.8 g, 97.5 mmol) and 2-oxopropanal (10 g, 140 mmol) was stirred for 5 minutes at room temperature. The resulting material was purified via silica gel chromatography (Eluant: 1:1 petroleum ether: ethyl acetate) to give the product as an oil, which was used directly in the next step. Yield: 12.5 g, 55.2 mmol, 57%.

1. customThe resulting material was purified via silica gel chromatography (Eluant: 1:1 petroleum ether: ethyl acetate)