tert-Butyl 4-[4-(4-fluorophenyl)-2-methyl-5-pyrimidin-4-yl-1H-imidazol-1-yl]piperidine-1-carboxylate → 4-[4-(4-Fluorophenyl)-2-methyl-1-piperidin-4-yl-1H-imidazol-5-yl]pyrimidine

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The title compound was prepared from tert-butyl 4-[4-(4-fluorophenyl)-2-methyl-5-pyrimidin-4-yl-1H-imidazol-1-yl]piperidine-1-carboxylate (C30) according to the general procedure for the synthesis of N-methyl-4-(4-phenyl-1-piperidin-4-yl-1H-imidazol-5-yl)pyrimidin-2-amine (C26) in Example 12, except in this case the extraction was carried out with dichloromethane. Yield: 35.7 mg, 0.106 mmol, 50%. LCMS m/z 338.5 (M+1). 1H NMR (400 MHz, CDCl3) δ 1.96-2.01 (m, 2H), 2.14-2.24 (m, 3H), 2.61-2.68 (m, 2H), 2.65 (s, 3H), 3.19-3.24 (m, 2H), 4.57 (tt, J=12.3, 3.9 Hz, 1H), 6.96 (dd, J=8.8, 8.8 Hz, 2H), 7.12 (dd, J=5.3, 1.4 Hz, 1H), 7.29 (dd, J=8.9, 5.5 Hz, 2H), 8.55 (d, J=5.3 Hz, 1H), 9.30 (d, J=1.3 Hz, 1H).

Provenance & Evidence