HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → 5-Furan-2yl-isoxazole-3-carboxylic acid (3-imidazol-1yl-propyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1H-Imidazole-1-propanamine | HCID 78736 | — |
| Reactant | 5-(2-Furyl)isoxazole-3-carboxylic acid | HCID 1090982 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Furan-2yl-isoxazole-3-carboxylic acid (3-imidazol-1yl-propyl)-amide | HCID 16003447 | 35% |
Reaction Steps
To a solution of 5-furan-2-yl-isoxazole-3-carboxylic acid (7 mg) and 3-imidazol-1-yl-propylamine (0.005 mL) in DMF were added HOBt (8 mg), EDC (9 mg) and TEA (0.014 mL). The resulting solution was stirred at a room temperature for 18 hours, and then concentrated under reduced pressure. The resulting concentrate was purified with preparative HPLC to give 4 mg of 5-furan-2-yl-isoxazole-3-carboxylic acid (3-imidazol-1-yl-propyl)-amide (yield: 35%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518978B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-45056c5d997a4ac3aba2b4e33a90ddb2 |
| Source note | uspto-grants-2013_08 |