Glycine methyl ester → HCID 86251955, compound

Participants

Reaction Steps

14.5 g (66.8 mmol) of 2-bromo-1-(4-fluorophenyl)ethanone and 5.42 g (66.8 mmol) of sodium thiocyanate were stirred in 250 ml of ethanol at 50° C. for 3 h. 5.95 g (66.8 mmol) of aminoacetic acid methyl ester (prepared from its hydrochloride) in 25 ml of ethanol were added, and the reaction mixture was stirred at room temperature for 4 h and allowed to stand overnight. After concentrating, water and ethyl acetate were added to the residue. The organic phase was separated, washed with water, dried and concentrated. Yield: 8.6 g (48%).

Provenance & Evidence