참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Fluoro-5-nitroaniline | HCID 67785 | — |
| 반응물 | Sodium sulfide nonahydrate | HCID 73972 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Amino-4-nitrobenzenethiol | HCID 6336400 | 100.8% |
반응 단계
2-Fluoro-5-nitroaniline (1 g, 6.41 mmol), sodium sulfide nonahydrate (1.7 g, 7.05 mmol), sodium bicarbonate (600 mg, 7.05 mmol) and water (15 mL) were combined and heated in the microwave at 125° C. for 5 min. After cooling, dichloromethane was added, and the organic layer was washed with 2M aqueous hydrochloric acid and then brine. The combined organic layers were dried over anhydrous MgSO4 and evaporated to afford 1.1 g (33%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08518980B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_08 |
|---|
| ORD ID | ord-e9c5997c6d844913b6436a312ef63ad8 |
|---|
| 출처 메모 | uspto-grants-2013_08 |
|---|
