HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoroethanol → 2,6-Dimethyl-4-trifluoroethoxyphenylacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Methyl 2-(4-bromo-2,6-dimethylphenyl)acetate | HCID 22889389 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2,6-Dimethyl-4-trifluoroethoxyphenylacetic acid | HCID 59612067 | — |
Reaction Steps
18.05 g (451 mmol) of sodium hydride are initially charged in 500 ml of DMF. 41.05 g (410 mmol) of trifluoroethanol are added dropwise, after the evolution of gas has ended 15.63 g (82 mmol) of copper(I) iodide are added, a solution of 21.10 g (82 mmol) of methyl 2,6-dimethyl-4-bromophenylacetate in 100 ml of DMF is slowly added dropwise and the mixture is boiled at reflux for 2.5 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518985B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-3954e09c79a14f3e808f585f4d59d02d |
| Source note | uspto-grants-2013_08 |