反应详情

To a flask containing tert-butyl 3-(2-(((benzyloxy)carbonyl)amino)acetamido)azetidine-1-carboxylate (9.26 g, 25.5 mmol) and a stirbar, was added 10% Pd/C (1.356 g, 1.27 mmol). The flask was evacuated and back filled with argon. Methanol (100 mL) was carefully added via syringe and the flask was evacuated with stirring. It was then back filled with hydrogen and stirred 2 days under a hydrogen balloon. After evacuation with stirring and back filling with argon, the catalyst was removed by filtration over Celite 521 and concentrated in vacuo to afford the product.

1. customThe flask was evacuated
2. additionback filled with argon
3. additionMethanol (100 mL) was carefully added via syringe
4. customthe flask was evacuated
5. additionIt was then back filled with hydrogen
6. stirringstirred 2 days under a hydrogen balloon
7. stirringAfter evacuation with stirring
8. customthe catalyst was removed by filtration over Celite 521
9. concentrationconcentrated in vacuo
10. customto afford the product